article-title: Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

article-type: research-article


article-title: The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements


article-title: The <i>Drosophila</i> EGF domain protein uninflatable sets the switch between wrapping glia growth and axon wrapping instructed by Notch


article-title: Automatic learning mechanisms for flexible human locomotion


article-title: Information, certainty, and learning


article-title: Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B


article-title: Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells


article-title: Cryo-EM structure revealed a novel F-actin binding motif in a <i>Legionella pneumophila</i> lysine fatty acyltransferase


article-title: Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche


article-title: Allosteric effects of the coupling cation in melibiose transporter MelB


article-title: Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision-making


article-title: The representation of facial emotion expands from sensory to prefrontal cortex with development


article-title: A forebrain hub for cautious actions via the midbrain


article-title: Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis


article-title: Human brain dynamics and spatiotemporal trajectories during threat processing


article-title: Feeding rates in sessile versus motile ciliates are hydrodynamically equivalent


article-title: Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during mouse skeletal muscle regeneration

article-type: short-report


article-title: Retraction: PAK3 downregulation induces cognitive impairment following cranial irradiation

article-type: retraction


article-title: Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco-flavored e-cigarette-exposed mouse lungs


article-title: Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function


article-title: Correction: Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

article-type: correction


article-title: Accelerated evolution in networked metapopulations of <i>Pseudomonas aeruginosa</i>


article-title: Gut microbe-derived trimethylamine shapes circadian rhythms through the host receptor TAAR5

article-type: research-advance


article-title: Transformer-based spatial–temporal detection of apoptotic cell death in live-cell imaging

article-type: tools-resources


article-title: Identifying regulators of associative learning using a protein-labelling approach in <i>Caenorhabditis elegans</i>


article-title: Executive resources shape the impact of language predictability across the adult lifespan


article-title: Mast cells promote pathology and susceptibility in tuberculosis


article-title: Global risk mapping of highly pathogenic avian influenza H5N1 and H5Nx in the light of epidemic episodes occurring from 2020 onwards


article-title: Inhibitory circuits control leg movements during <i>Drosophila</i> grooming


article-title: Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors


article-title: TRPV3 channel activity helps cortical neurons stay active during fever


article-title: Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output


article-title: Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology


article-title: Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation)


article-title: Structural characterisation of chromatin remodelling intermediates supports linker DNA-dependent product inhibition as a mechanism for nucleosome spacing


article-title: <i>cxcl18b</i>-defined transitional state-specific nitric oxide drives injury-induced Müller glia cell-cycle re-entry in the zebrafish retina


article-title: Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β


article-title: Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity


article-title: Sex-specific exploration accounts for differences in valence learning in male and female mice


article-title: Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV


article-title: The IBEX knowledge-base a community resource enabling adoption and development of immunofluorescence imaging methods


article-title: Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum


article-title: HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir


article-title: Robust assessment of asymmetric division in colon cancer cells


article-title: A single-cell atlas of the testicular interstitium defines Leydig progenitor networks sustaining Leydig cell homeostasis across the lifespan


article-title: Feedback of peripheral saccade targets to early foveal cortex


article-title: The cellular logic of limb regeneration

article-type: insight


article-title: A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation


article-title: Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol


article-title: Anti-resonance in developmental signaling regulates cell fate decisions


article-title: Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy


article-title: Western lifestyle linked to maladaptive trained immunity

article-type: review-article


article-title: Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase


article-title: Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy)


article-title: Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment


article-title: Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of osteoarthritis


article-title: ATAD2 mediates chromatin-bound histone chaperone turnover


article-title: Linking neuron-glia interactions and longevity


article-title: GMCL1 controls 53BP1 stability and modulates taxane sensitivity


article-title: Predicting human decision-making across task conditions via individuality transfer


article-title: A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis


article-title: Targeted computational design of an interleukin-7 superkine with enhanced folding efficiency and immunotherapeutic efficacy


article-title: Glial <i>betaPix</i> is essential for blood vessel development in the zebrafish brain


article-title: Biologically informed cortical models predict optogenetic perturbations


article-title: Stratification of viral shedding patterns in saliva of COVID-19 patients


article-title: A dynamic scale-mixture model of motion in natural scenes


article-title: Rtf1-dependent transcriptional pausing regulates cardiogenesis


article-title: Going beyond compliance to build on the Researcher Development Concordat

article-type: feature


article-title: Trained immunity in acute and chronic neurological diseases


article-title: Association between continuous glucose monitoring-derived metrics and coronary plaque vulnerability: A retrospective exploratory analysis


article-title: Functionally coupled ion channels begin co-assembling at the start of their synthesis


article-title: A systematic review and embryological perspective of pluripotent stem cell-derived autonomic postganglionic neuron differentiation for human disease modeling


article-title: A unifying account of replay as context-driven memory reactivation


article-title: Secreted exosomes induce filopodia formation


article-title: Afadin sorts different retinal neuron types into accurate cellular layers


article-title: Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response


article-title: The RNA-binding protein HuR modulates the expression of the disease-linked <i>CCL2</i> rs1024611G-rs13900T haplotype


article-title: Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity


article-title: Insights from aquaporin structures into drug-resistant sleeping sickness


article-title: Nonlinear transcriptional responses to gradual modulation of transcription factor dosage


article-title: Finding a role for non-coding DNA in trypanosomes


article-title: Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals


article-title: Establishing synthetic ribbon-type active zones in a heterologous expression system


article-title: Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka


article-title: ATP burst is the dominant driver of antibiotic lethality in <i>Mycobacterium smegmatis</i>


article-title: Between-species variation in neocortical sulcal anatomy of the carnivoran brain


article-title: Transcriptional subtypes on immune microenvironment and predicting postoperative recurrence and metastasis in human pheochromocytoma and paraganglioma


article-title: Linking complex microbial interactions and dysbiosis through a disordered Lotka–Volterra model


article-title: Predicting the effect of CRISPR-Cas9-based epigenome editing


article-title: Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance


article-title: Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake


article-title: Dilated cardiomyopathy-associated RNA-binding motif protein 20 regulates long pre-mRNAs in neurons


article-title: A geometric shape regularity effect in the human brain


article-title: Lipid balance and chemoresistance in cancer cells


article-title: PCBP2 as an intrinsic aging factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis


article-title: Two classes of amine/glutamate multi-transmitter neurons innervate Drosophila internal male reproductive organs


article-title: Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation


article-title: The interplay between biomolecular assembly and phase separation


article-title: Short activation domains control chromatin association of transcription factors