eLife: reviewed-preprints

eLife: reviewed-preprints https://elifesciences.org The latest eLife reviewed preprints http://www.rssboard.org/rss-specification observer (using python-feedgen) en Sat, 16 May 2026 02:12:46 +0000 Assessing plant phenological changes based on drivers of spring phenology https://elifesciences.org/reviewed-preprints/106655 https://elifesciences.org/reviewed-preprints/106655 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins https://elifesciences.org/reviewed-preprints/105314 https://elifesciences.org/reviewed-preprints/105314 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z Calibration and validation strategy for electromechanical cardiac digital twins https://elifesciences.org/reviewed-preprints/106555 https://elifesciences.org/reviewed-preprints/106555 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation Change https://elifesciences.org/reviewed-preprints/106924 https://elifesciences.org/reviewed-preprints/106924 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming https://elifesciences.org/reviewed-preprints/106601 https://elifesciences.org/reviewed-preprints/106601 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z The Structural Dynamics of IRE1 and its Interaction with Unfolded Peptides https://elifesciences.org/reviewed-preprints/106716 https://elifesciences.org/reviewed-preprints/106716 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z The influence of heavy metal stress on the evolutionary transition of teosinte to maize https://elifesciences.org/reviewed-preprints/105858 https://elifesciences.org/reviewed-preprints/105858 Wed, 04 Jun 2025 14:00:00 +0000 2025-06-04T14:00:00Z Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes https://elifesciences.org/reviewed-preprints/106611 https://elifesciences.org/reviewed-preprints/106611 Tue, 03 Jun 2025 14:00:00 +0000 2025-06-03T14:00:00Z The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice https://elifesciences.org/reviewed-preprints/106616 https://elifesciences.org/reviewed-preprints/106616 Tue, 03 Jun 2025 14:00:00 +0000 2025-06-03T14:00:00Z High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains https://elifesciences.org/reviewed-preprints/106811 https://elifesciences.org/reviewed-preprints/106811 Tue, 03 Jun 2025 10:00:00 +0000 2025-06-03T10:00:00Z A geometric shape regularity effect in the human brain https://elifesciences.org/reviewed-preprints/106464 https://elifesciences.org/reviewed-preprints/106464 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Deep Learning Reveals Endogenous Sterols as Allosteric Modulators of the GPCR-Gα Interface https://elifesciences.org/reviewed-preprints/106397 https://elifesciences.org/reviewed-preprints/106397 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices: Glucose-Dependent Modulation of IP3 Receptor-Specific Responses https://elifesciences.org/reviewed-preprints/106679 https://elifesciences.org/reviewed-preprints/106679 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Linage priming and cell type proportioning depends on the interplay between stochastic and deterministic factors https://elifesciences.org/reviewed-preprints/105512 https://elifesciences.org/reviewed-preprints/105512 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Sphingolipid imbalance aggravates tau pathology by endomembrane rigidification and rupture https://elifesciences.org/reviewed-preprints/106865 https://elifesciences.org/reviewed-preprints/106865 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus https://elifesciences.org/reviewed-preprints/106890 https://elifesciences.org/reviewed-preprints/106890 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z The integration mechanism of the four positional cues—anterior, posterior, dorsal, and ventral—in axolotl limb regeneration https://elifesciences.org/reviewed-preprints/106917 https://elifesciences.org/reviewed-preprints/106917 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells https://elifesciences.org/reviewed-preprints/107104 https://elifesciences.org/reviewed-preprints/107104 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Aging-associated Increase of GATA4 levels in Articular Cartilage is Linked to Impaired Regenerative Capacity of Chondrocytes and Osteoarthritis https://elifesciences.org/reviewed-preprints/106224 https://elifesciences.org/reviewed-preprints/106224 Thu, 29 May 2025 14:00:00 +0000 2025-05-29T14:00:00Z Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy https://elifesciences.org/reviewed-preprints/106389 https://elifesciences.org/reviewed-preprints/106389 Thu, 29 May 2025 14:00:00 +0000 2025-05-29T14:00:00Z SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling https://elifesciences.org/reviewed-preprints/106338 https://elifesciences.org/reviewed-preprints/106338 Thu, 29 May 2025 14:00:00 +0000 2025-05-29T14:00:00Z Synonymous mutations in AAV Rep enhance genome packaging in a library selection https://elifesciences.org/reviewed-preprints/105040 https://elifesciences.org/reviewed-preprints/105040 Thu, 29 May 2025 14:00:00 +0000 2025-05-29T14:00:00Z Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5 https://elifesciences.org/reviewed-preprints/107037 https://elifesciences.org/reviewed-preprints/107037 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach https://elifesciences.org/reviewed-preprints/107025 https://elifesciences.org/reviewed-preprints/107025 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16 https://elifesciences.org/reviewed-preprints/106265 https://elifesciences.org/reviewed-preprints/106265 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C https://elifesciences.org/reviewed-preprints/105580 https://elifesciences.org/reviewed-preprints/105580 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Type I interferon responses contribute to immune protection against mycobacterial infection https://elifesciences.org/reviewed-preprints/106799 https://elifesciences.org/reviewed-preprints/106799 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation https://elifesciences.org/reviewed-preprints/107018 https://elifesciences.org/reviewed-preprints/107018 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers https://elifesciences.org/reviewed-preprints/106979 https://elifesciences.org/reviewed-preprints/106979 Tue, 27 May 2025 14:00:00 +0000 2025-05-27T14:00:00Z Structural mechanism of strand exchange by the RAD51 filament https://elifesciences.org/reviewed-preprints/107114 https://elifesciences.org/reviewed-preprints/107114 Tue, 27 May 2025 10:00:00 +0000 2025-05-27T10:00:00Z Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activity https://elifesciences.org/reviewed-preprints/106330 https://elifesciences.org/reviewed-preprints/106330 Fri, 23 May 2025 14:00:00 +0000 2025-05-23T14:00:00Z Gene expression variation across genetically identical individuals predicts reproductive traits https://elifesciences.org/reviewed-preprints/106525 https://elifesciences.org/reviewed-preprints/106525 Fri, 23 May 2025 14:00:00 +0000 2025-05-23T14:00:00Z GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer https://elifesciences.org/reviewed-preprints/106730 https://elifesciences.org/reviewed-preprints/106730 Fri, 23 May 2025 14:00:00 +0000 2025-05-23T14:00:00Z Mapping of in vivo cleavage sites uncovers a major role for yeast RNase III in regulating protein-coding genes https://elifesciences.org/reviewed-preprints/106662 https://elifesciences.org/reviewed-preprints/106662 Fri, 23 May 2025 14:00:00 +0000 2025-05-23T14:00:00Z Progressive mural cell deficiencies across the lifespan in a foxf2 model of Cerebral Small Vessel Disease https://elifesciences.org/reviewed-preprints/106720 https://elifesciences.org/reviewed-preprints/106720 Fri, 23 May 2025 14:00:00 +0000 2025-05-23T14:00:00Z Forecasting protein evolution by integrating birth-death population models with structurally constrained substitution models https://elifesciences.org/reviewed-preprints/106365 https://elifesciences.org/reviewed-preprints/106365 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome https://elifesciences.org/reviewed-preprints/106231 https://elifesciences.org/reviewed-preprints/106231 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Sending mixed signals: convergent iridescence and divergent chemical signals in sympatric sister-species of Amazonian butterflies https://elifesciences.org/reviewed-preprints/106098 https://elifesciences.org/reviewed-preprints/106098 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape https://elifesciences.org/reviewed-preprints/106566 https://elifesciences.org/reviewed-preprints/106566 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers https://elifesciences.org/reviewed-preprints/106861 https://elifesciences.org/reviewed-preprints/106861 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Unsupervised reference-free inference reveals unrecognized regulated transcriptomic complexity in human single cells https://elifesciences.org/reviewed-preprints/105979 https://elifesciences.org/reviewed-preprints/105979 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice https://elifesciences.org/reviewed-preprints/106273 https://elifesciences.org/reviewed-preprints/106273 Wed, 21 May 2025 14:00:00 +0000 2025-05-21T14:00:00Z Chemostat culturing reduces fecal eukaryotic virus load and delays diarrhea after virome transplantation https://elifesciences.org/reviewed-preprints/105991 https://elifesciences.org/reviewed-preprints/105991 Wed, 21 May 2025 14:00:00 +0000 2025-05-21T14:00:00Z Locus coeruleus modulation of single-cell representation and population dynamics in the mouse prefrontal cortex during attentional switching https://elifesciences.org/reviewed-preprints/105911 https://elifesciences.org/reviewed-preprints/105911 Wed, 21 May 2025 14:00:00 +0000 2025-05-21T14:00:00Z Single-cell profiling of the lung immune cells of diabetes-tuberculosis comorbidity reveals reduced type-II interferon and elevated Th17 responses https://elifesciences.org/reviewed-preprints/106025 https://elifesciences.org/reviewed-preprints/106025 Wed, 21 May 2025 14:00:00 +0000 2025-05-21T14:00:00Z Virtual Brain Inference (VBI): A flexible and integrative toolkit for efficient probabilistic inference on virtual brain models https://elifesciences.org/reviewed-preprints/106194 https://elifesciences.org/reviewed-preprints/106194 Wed, 21 May 2025 14:00:00 +0000 2025-05-21T14:00:00Z Atherosclerosis, Intracranial Aneurysms, and Intermediate Biomarkers: Real-World Observational and Mendelian Randomization Research https://elifesciences.org/reviewed-preprints/106521 https://elifesciences.org/reviewed-preprints/106521 Tue, 20 May 2025 14:00:00 +0000 2025-05-20T14:00:00Z Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes https://elifesciences.org/reviewed-preprints/106728 https://elifesciences.org/reviewed-preprints/106728 Tue, 20 May 2025 14:00:00 +0000 2025-05-20T14:00:00Z Shining light on the dark matter of pertussis: evidence for an asymptomatic carriage state from a longitudinal cohort of mother/infant dyads https://elifesciences.org/reviewed-preprints/106139 https://elifesciences.org/reviewed-preprints/106139 Tue, 20 May 2025 10:00:00 +0000 2025-05-20T10:00:00Z Hierarchical encoding of natural sounds mixtures in ferret auditory cortex https://elifesciences.org/reviewed-preprints/106628 https://elifesciences.org/reviewed-preprints/106628 Mon, 19 May 2025 14:00:00 +0000 2025-05-19T14:00:00Z Transcriptional coregulation in cis around a contact insulation site revealed by single-molecule microscopy https://elifesciences.org/reviewed-preprints/106678 https://elifesciences.org/reviewed-preprints/106678 Fri, 16 May 2025 14:00:00 +0000 2025-05-16T14:00:00Z Cross-species insemination reveals mouse sperm ability to enter and cross the fish micropyle https://elifesciences.org/reviewed-preprints/106303 https://elifesciences.org/reviewed-preprints/106303 Thu, 15 May 2025 14:00:00 +0000 2025-05-15T14:00:00Z Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence https://elifesciences.org/reviewed-preprints/106403 https://elifesciences.org/reviewed-preprints/106403 Thu, 15 May 2025 14:00:00 +0000 2025-05-15T14:00:00Z Single-Cell Atlas of AML Reveals Age-Related Gene Regulatory Networks in t(8;21) AML https://elifesciences.org/reviewed-preprints/104978 https://elifesciences.org/reviewed-preprints/104978 Thu, 15 May 2025 14:00:00 +0000 2025-05-15T14:00:00Z TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer https://elifesciences.org/reviewed-preprints/106196 https://elifesciences.org/reviewed-preprints/106196 Thu, 15 May 2025 14:00:00 +0000 2025-05-15T14:00:00Z A theory of brain-computer interface learning via low-dimensional control https://elifesciences.org/reviewed-preprints/106309 https://elifesciences.org/reviewed-preprints/106309 Wed, 14 May 2025 14:00:00 +0000 2025-05-14T14:00:00Z Modular DNA Barcoding of Nanobodies Enables Multiplexed in situ Protein Imaging and High-throughput Biomolecule Detection https://elifesciences.org/reviewed-preprints/105225 https://elifesciences.org/reviewed-preprints/105225 Wed, 14 May 2025 14:00:00 +0000 2025-05-14T14:00:00Z Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response https://elifesciences.org/reviewed-preprints/107157 https://elifesciences.org/reviewed-preprints/107157 Wed, 14 May 2025 14:00:00 +0000 2025-05-14T14:00:00Z A Stimulus-Computable Model for Audiovisual Perception and Spatial Orienting in Mammals https://elifesciences.org/reviewed-preprints/106122 https://elifesciences.org/reviewed-preprints/106122 Tue, 13 May 2025 14:00:00 +0000 2025-05-13T14:00:00Z Cellular and synaptic organization of the Octopus vertical lobe https://elifesciences.org/reviewed-preprints/105973 https://elifesciences.org/reviewed-preprints/105973 Tue, 13 May 2025 14:00:00 +0000 2025-05-13T14:00:00Z Collective epithelial migration mediated by the unbinding of hexatic defects https://elifesciences.org/reviewed-preprints/105397 https://elifesciences.org/reviewed-preprints/105397 Tue, 13 May 2025 14:00:00 +0000 2025-05-13T14:00:00Z Fitness drivers of division of labor in vertebrates https://elifesciences.org/reviewed-preprints/105501 https://elifesciences.org/reviewed-preprints/105501 Tue, 13 May 2025 14:00:00 +0000 2025-05-13T14:00:00Z Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization https://elifesciences.org/reviewed-preprints/101584 https://elifesciences.org/reviewed-preprints/101584 Mon, 12 May 2025 14:00:00 +0000 2025-05-12T14:00:00Z Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity https://elifesciences.org/reviewed-preprints/106362 https://elifesciences.org/reviewed-preprints/106362 Mon, 12 May 2025 14:00:00 +0000 2025-05-12T14:00:00Z Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer Cells https://elifesciences.org/reviewed-preprints/106657 https://elifesciences.org/reviewed-preprints/106657 Mon, 12 May 2025 14:00:00 +0000 2025-05-12T14:00:00Z Disinformation elicits learning biases https://elifesciences.org/reviewed-preprints/106073 https://elifesciences.org/reviewed-preprints/106073 Mon, 12 May 2025 14:00:00 +0000 2025-05-12T14:00:00Z Five-Year Survival Outcomes for Breast Cancer Patients Across Continental Africa: A Contemporary Review of Literature with Meta Analysis https://elifesciences.org/reviewed-preprints/105488 https://elifesciences.org/reviewed-preprints/105488 Mon, 12 May 2025 14:00:00 +0000 2025-05-12T14:00:00Z Making plant tissue accessible for cryo-electron tomography https://elifesciences.org/reviewed-preprints/106455 https://elifesciences.org/reviewed-preprints/106455 Mon, 12 May 2025 14:00:00 +0000 2025-05-12T14:00:00Z MorphoNet 2.0: An innovative approach for qualitative assessment and segmentation curation of large-scale 3D time-lapse imaging datasets https://elifesciences.org/reviewed-preprints/106227 https://elifesciences.org/reviewed-preprints/106227 Mon, 12 May 2025 14:00:00 +0000 2025-05-12T14:00:00Z Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume https://elifesciences.org/reviewed-preprints/106602 https://elifesciences.org/reviewed-preprints/106602 Mon, 12 May 2025 14:00:00 +0000 2025-05-12T14:00:00Z p66Shc Mediates SUMO2-induced Endothelial Dysfunction https://elifesciences.org/reviewed-preprints/106344 https://elifesciences.org/reviewed-preprints/106344 Mon, 12 May 2025 14:00:00 +0000 2025-05-12T14:00:00Z A tissue boundary orchestrates the segregation of inner ear sensory organs https://elifesciences.org/reviewed-preprints/106305 https://elifesciences.org/reviewed-preprints/106305 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics https://elifesciences.org/reviewed-preprints/106508 https://elifesciences.org/reviewed-preprints/106508 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Domain Coupling in Allosteric Regulation of SthK Measured Using Time-Resolved Transition Metal Ion FRET https://elifesciences.org/reviewed-preprints/106892 https://elifesciences.org/reviewed-preprints/106892 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z map3k1 is required for spatial restriction of progenitor differentiation in planarians https://elifesciences.org/reviewed-preprints/106439 https://elifesciences.org/reviewed-preprints/106439 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development https://elifesciences.org/reviewed-preprints/105932 https://elifesciences.org/reviewed-preprints/105932 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies https://elifesciences.org/reviewed-preprints/106156 https://elifesciences.org/reviewed-preprints/106156 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Genetic evidence: zebrafish hoxba and hoxbb clusters are essential for the anterior-posterior positioning of pectoral fins https://elifesciences.org/reviewed-preprints/105889 https://elifesciences.org/reviewed-preprints/105889 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Genetic parallels in biomineralization of the calcareous sponge Sycon ciliatum and stony corals https://elifesciences.org/reviewed-preprints/106239 https://elifesciences.org/reviewed-preprints/106239 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Identification and classification of ion-channels across the tree of life: Insights into understudied CALHM channels https://elifesciences.org/reviewed-preprints/106134 https://elifesciences.org/reviewed-preprints/106134 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Krüppel Regulates Cell Cycle Exit and Limits Adult Neurogenesis of Mushroom Body Neural Progenitors in Drosophila https://elifesciences.org/reviewed-preprints/106732 https://elifesciences.org/reviewed-preprints/106732 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics https://elifesciences.org/reviewed-preprints/106587 https://elifesciences.org/reviewed-preprints/106587 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Spiral-eyes: A soft active matter model of in vivo corneal epithelial cell migration https://elifesciences.org/reviewed-preprints/106061 https://elifesciences.org/reviewed-preprints/106061 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Targeted Protein Degradation by KLHDC2 Ligands Identified by High Throughput Screening https://elifesciences.org/reviewed-preprints/106844 https://elifesciences.org/reviewed-preprints/106844 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z The alternative oxidase reconfigures the larval mitochondrial electron transport system to accelerate growth and development in Drosophila melanogaster https://elifesciences.org/reviewed-preprints/106202 https://elifesciences.org/reviewed-preprints/106202 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response https://elifesciences.org/reviewed-preprints/106901 https://elifesciences.org/reviewed-preprints/106901 Fri, 09 May 2025 14:00:00 +0000 2025-05-09T14:00:00Z Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy https://elifesciences.org/reviewed-preprints/106697 https://elifesciences.org/reviewed-preprints/106697 Thu, 08 May 2025 14:00:00 +0000 2025-05-08T14:00:00Z Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response https://elifesciences.org/reviewed-preprints/106484 https://elifesciences.org/reviewed-preprints/106484 Wed, 07 May 2025 14:00:00 +0000 2025-05-07T14:00:00Z Evidence for systematic - yet task- and motor-contingent - rhythmicity of auditory perceptual judgements https://elifesciences.org/reviewed-preprints/105734 https://elifesciences.org/reviewed-preprints/105734 Wed, 07 May 2025 14:00:00 +0000 2025-05-07T14:00:00Z Heritability of movie-evoked brain activity and connectivity https://elifesciences.org/reviewed-preprints/106081 https://elifesciences.org/reviewed-preprints/106081 Wed, 07 May 2025 14:00:00 +0000 2025-05-07T14:00:00Z Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis https://elifesciences.org/reviewed-preprints/106896 https://elifesciences.org/reviewed-preprints/106896 Wed, 07 May 2025 14:00:00 +0000 2025-05-07T14:00:00Z Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds https://elifesciences.org/reviewed-preprints/106252 https://elifesciences.org/reviewed-preprints/106252 Wed, 07 May 2025 14:00:00 +0000 2025-05-07T14:00:00Z Monocyte-derived macrophage recruitment mediated by TRPV1 is required for eardrum wound healing https://elifesciences.org/reviewed-preprints/106393 https://elifesciences.org/reviewed-preprints/106393 Wed, 07 May 2025 14:00:00 +0000 2025-05-07T14:00:00Z Protein Language Model Identifies Disordered, Conserved Motifs Driving Phase Separation https://elifesciences.org/reviewed-preprints/105309 https://elifesciences.org/reviewed-preprints/105309 Wed, 07 May 2025 14:00:00 +0000 2025-05-07T14:00:00Z Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers https://elifesciences.org/reviewed-preprints/104926 https://elifesciences.org/reviewed-preprints/104926 Wed, 07 May 2025 14:00:00 +0000 2025-05-07T14:00:00Z Ribosomal RNA synthesis by RNA polymerase I is regulated by premature termination of transcription https://elifesciences.org/reviewed-preprints/106503 https://elifesciences.org/reviewed-preprints/106503 Wed, 07 May 2025 14:00:00 +0000 2025-05-07T14:00:00Z Sparse innervation and local heterogeneity in the vibrissal corticostriatal projection https://elifesciences.org/reviewed-preprints/106621 https://elifesciences.org/reviewed-preprints/106621 Wed, 07 May 2025 14:00:00 +0000 2025-05-07T14:00:00Z Unprecedented Number of Recurrent Mutations Drive the Rapid Evolution of Pesticide Resistance in a Notorious Pest https://elifesciences.org/reviewed-preprints/106288 https://elifesciences.org/reviewed-preprints/106288 Wed, 07 May 2025 14:00:00 +0000 2025-05-07T14:00:00Z KDM5 demethylases suppress R-loop-mediated “viral mimicry” and DNA damage in breast cancer cells https://elifesciences.org/reviewed-preprints/106249 https://elifesciences.org/reviewed-preprints/106249 Tue, 06 May 2025 14:00:00 +0000 2025-05-06T14:00:00Z Single-cell type analysis of wing premotor circuits in the ventral nerve cord of Drosophila melanogaster https://elifesciences.org/reviewed-preprints/106548 https://elifesciences.org/reviewed-preprints/106548 Tue, 06 May 2025 10:00:00 +0000 2025-05-06T10:00:00Z