eLife: reviewed-preprints

eLife: reviewed-preprints https://elifesciences.org The latest eLife reviewed preprints http://www.rssboard.org/rss-specification observer (using python-feedgen) en Sat, 16 May 2026 02:12:47 +0000 Assessing plant phenological changes based on drivers of spring phenology https://elifesciences.org/reviewed-preprints/106655 https://elifesciences.org/reviewed-preprints/106655 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins https://elifesciences.org/reviewed-preprints/105314 https://elifesciences.org/reviewed-preprints/105314 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z Calibration and validation strategy for electromechanical cardiac digital twins https://elifesciences.org/reviewed-preprints/106555 https://elifesciences.org/reviewed-preprints/106555 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation Change https://elifesciences.org/reviewed-preprints/106924 https://elifesciences.org/reviewed-preprints/106924 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming https://elifesciences.org/reviewed-preprints/106601 https://elifesciences.org/reviewed-preprints/106601 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z The Structural Dynamics of IRE1 and its Interaction with Unfolded Peptides https://elifesciences.org/reviewed-preprints/106716 https://elifesciences.org/reviewed-preprints/106716 Thu, 05 Jun 2025 14:00:00 +0000 2025-06-05T14:00:00Z The influence of heavy metal stress on the evolutionary transition of teosinte to maize https://elifesciences.org/reviewed-preprints/105858 https://elifesciences.org/reviewed-preprints/105858 Wed, 04 Jun 2025 14:00:00 +0000 2025-06-04T14:00:00Z Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes https://elifesciences.org/reviewed-preprints/106611 https://elifesciences.org/reviewed-preprints/106611 Tue, 03 Jun 2025 14:00:00 +0000 2025-06-03T14:00:00Z The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice https://elifesciences.org/reviewed-preprints/106616 https://elifesciences.org/reviewed-preprints/106616 Tue, 03 Jun 2025 14:00:00 +0000 2025-06-03T14:00:00Z High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains https://elifesciences.org/reviewed-preprints/106811 https://elifesciences.org/reviewed-preprints/106811 Tue, 03 Jun 2025 10:00:00 +0000 2025-06-03T10:00:00Z A geometric shape regularity effect in the human brain https://elifesciences.org/reviewed-preprints/106464 https://elifesciences.org/reviewed-preprints/106464 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Deep Learning Reveals Endogenous Sterols as Allosteric Modulators of the GPCR-Gα Interface https://elifesciences.org/reviewed-preprints/106397 https://elifesciences.org/reviewed-preprints/106397 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices: Glucose-Dependent Modulation of IP3 Receptor-Specific Responses https://elifesciences.org/reviewed-preprints/106679 https://elifesciences.org/reviewed-preprints/106679 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Linage priming and cell type proportioning depends on the interplay between stochastic and deterministic factors https://elifesciences.org/reviewed-preprints/105512 https://elifesciences.org/reviewed-preprints/105512 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Sphingolipid imbalance aggravates tau pathology by endomembrane rigidification and rupture https://elifesciences.org/reviewed-preprints/106865 https://elifesciences.org/reviewed-preprints/106865 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus https://elifesciences.org/reviewed-preprints/106890 https://elifesciences.org/reviewed-preprints/106890 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z The integration mechanism of the four positional cues—anterior, posterior, dorsal, and ventral—in axolotl limb regeneration https://elifesciences.org/reviewed-preprints/106917 https://elifesciences.org/reviewed-preprints/106917 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells https://elifesciences.org/reviewed-preprints/107104 https://elifesciences.org/reviewed-preprints/107104 Fri, 30 May 2025 14:00:00 +0000 2025-05-30T14:00:00Z Aging-associated Increase of GATA4 levels in Articular Cartilage is Linked to Impaired Regenerative Capacity of Chondrocytes and Osteoarthritis https://elifesciences.org/reviewed-preprints/106224 https://elifesciences.org/reviewed-preprints/106224 Thu, 29 May 2025 14:00:00 +0000 2025-05-29T14:00:00Z Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy https://elifesciences.org/reviewed-preprints/106389 https://elifesciences.org/reviewed-preprints/106389 Thu, 29 May 2025 14:00:00 +0000 2025-05-29T14:00:00Z SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling https://elifesciences.org/reviewed-preprints/106338 https://elifesciences.org/reviewed-preprints/106338 Thu, 29 May 2025 14:00:00 +0000 2025-05-29T14:00:00Z Synonymous mutations in AAV Rep enhance genome packaging in a library selection https://elifesciences.org/reviewed-preprints/105040 https://elifesciences.org/reviewed-preprints/105040 Thu, 29 May 2025 14:00:00 +0000 2025-05-29T14:00:00Z Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5 https://elifesciences.org/reviewed-preprints/107037 https://elifesciences.org/reviewed-preprints/107037 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach https://elifesciences.org/reviewed-preprints/107025 https://elifesciences.org/reviewed-preprints/107025 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16 https://elifesciences.org/reviewed-preprints/106265 https://elifesciences.org/reviewed-preprints/106265 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C https://elifesciences.org/reviewed-preprints/105580 https://elifesciences.org/reviewed-preprints/105580 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Type I interferon responses contribute to immune protection against mycobacterial infection https://elifesciences.org/reviewed-preprints/106799 https://elifesciences.org/reviewed-preprints/106799 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation https://elifesciences.org/reviewed-preprints/107018 https://elifesciences.org/reviewed-preprints/107018 Wed, 28 May 2025 14:00:00 +0000 2025-05-28T14:00:00Z Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers https://elifesciences.org/reviewed-preprints/106979 https://elifesciences.org/reviewed-preprints/106979 Tue, 27 May 2025 14:00:00 +0000 2025-05-27T14:00:00Z Structural mechanism of strand exchange by the RAD51 filament https://elifesciences.org/reviewed-preprints/107114 https://elifesciences.org/reviewed-preprints/107114 Tue, 27 May 2025 10:00:00 +0000 2025-05-27T10:00:00Z Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activity https://elifesciences.org/reviewed-preprints/106330 https://elifesciences.org/reviewed-preprints/106330 Fri, 23 May 2025 14:00:00 +0000 2025-05-23T14:00:00Z Gene expression variation across genetically identical individuals predicts reproductive traits https://elifesciences.org/reviewed-preprints/106525 https://elifesciences.org/reviewed-preprints/106525 Fri, 23 May 2025 14:00:00 +0000 2025-05-23T14:00:00Z GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer https://elifesciences.org/reviewed-preprints/106730 https://elifesciences.org/reviewed-preprints/106730 Fri, 23 May 2025 14:00:00 +0000 2025-05-23T14:00:00Z Mapping of in vivo cleavage sites uncovers a major role for yeast RNase III in regulating protein-coding genes https://elifesciences.org/reviewed-preprints/106662 https://elifesciences.org/reviewed-preprints/106662 Fri, 23 May 2025 14:00:00 +0000 2025-05-23T14:00:00Z Progressive mural cell deficiencies across the lifespan in a foxf2 model of Cerebral Small Vessel Disease https://elifesciences.org/reviewed-preprints/106720 https://elifesciences.org/reviewed-preprints/106720 Fri, 23 May 2025 14:00:00 +0000 2025-05-23T14:00:00Z Forecasting protein evolution by integrating birth-death population models with structurally constrained substitution models https://elifesciences.org/reviewed-preprints/106365 https://elifesciences.org/reviewed-preprints/106365 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome https://elifesciences.org/reviewed-preprints/106231 https://elifesciences.org/reviewed-preprints/106231 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Sending mixed signals: convergent iridescence and divergent chemical signals in sympatric sister-species of Amazonian butterflies https://elifesciences.org/reviewed-preprints/106098 https://elifesciences.org/reviewed-preprints/106098 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape https://elifesciences.org/reviewed-preprints/106566 https://elifesciences.org/reviewed-preprints/106566 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers https://elifesciences.org/reviewed-preprints/106861 https://elifesciences.org/reviewed-preprints/106861 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Unsupervised reference-free inference reveals unrecognized regulated transcriptomic complexity in human single cells https://elifesciences.org/reviewed-preprints/105979 https://elifesciences.org/reviewed-preprints/105979 Thu, 22 May 2025 14:00:00 +0000 2025-05-22T14:00:00Z Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice https://elifesciences.org/reviewed-preprints/106273 https://elifesciences.org/reviewed-preprints/106273 Wed, 21 May 2025 14:00:00 +0000 2025-05-21T14:00:00Z Chemostat culturing reduces fecal eukaryotic virus load and delays diarrhea after virome transplantation https://elifesciences.org/reviewed-preprints/105991 https://elifesciences.org/reviewed-preprints/105991 Wed, 21 May 2025 14:00:00 +0000 2025-05-21T14:00:00Z Locus coeruleus modulation of single-cell representation and population dynamics in the mouse prefrontal cortex during attentional switching https://elifesciences.org/reviewed-preprints/105911 https://elifesciences.org/reviewed-preprints/105911 Wed, 21 May 2025 14:00:00 +0000 2025-05-21T14:00:00Z Single-cell profiling of the lung immune cells of diabetes-tuberculosis comorbidity reveals reduced type-II interferon and elevated Th17 responses https://elifesciences.org/reviewed-preprints/106025 https://elifesciences.org/reviewed-preprints/106025 Wed, 21 May 2025 14:00:00 +0000 2025-05-21T14:00:00Z Virtual Brain Inference (VBI): A flexible and integrative toolkit for efficient probabilistic inference on virtual brain models https://elifesciences.org/reviewed-preprints/106194 https://elifesciences.org/reviewed-preprints/106194 Wed, 21 May 2025 14:00:00 +0000 2025-05-21T14:00:00Z Atherosclerosis, Intracranial Aneurysms, and Intermediate Biomarkers: Real-World Observational and Mendelian Randomization Research https://elifesciences.org/reviewed-preprints/106521 https://elifesciences.org/reviewed-preprints/106521 Tue, 20 May 2025 14:00:00 +0000 2025-05-20T14:00:00Z Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes https://elifesciences.org/reviewed-preprints/106728 https://elifesciences.org/reviewed-preprints/106728 Tue, 20 May 2025 14:00:00 +0000 2025-05-20T14:00:00Z Shining light on the dark matter of pertussis: evidence for an asymptomatic carriage state from a longitudinal cohort of mother/infant dyads https://elifesciences.org/reviewed-preprints/106139 https://elifesciences.org/reviewed-preprints/106139 Tue, 20 May 2025 10:00:00 +0000 2025-05-20T10:00:00Z Hierarchical encoding of natural sounds mixtures in ferret auditory cortex https://elifesciences.org/reviewed-preprints/106628 https://elifesciences.org/reviewed-preprints/106628 Mon, 19 May 2025 14:00:00 +0000 2025-05-19T14:00:00Z